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Blunted response to statin therapy

  • 21 mai 2019Moyen
A 53-year-old man presents with a low-density lipoprotein cholesterol (LDL-C) level of 136 mg/dL and a lipoprotein(a) [Lp(a)] level of 189 nmol/L. He elects to start rosuvastatin 20 mg/day. At follow-up, his LDL-C is 88 mg/dL, a 35% reduction. One would typically expect to see a ≥50% reduction with a high-dose statin regimen. What’s a likely reason for this patient's less-than-expected response to statin therapy?


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